Agmatine Sulfate (The NO Multiplier)

Also Known As: Super Arginine, 4-guanidinobutylamine, Decarboxylated Arginine

Compound Type: Nitric Oxide Potentiator / Neuromodulator

★★★★★ (5/5 Stars)

Agmatine is widely considered the “Secret Weapon” of advanced penis enlargement. Chemically, it is a metabolite of L-Arginine, but it acts very differently. While Arginine is the fuel for nitric oxide, Agmatine is the turbocharger.

It works by modulating the enzymes that destroy Nitric Oxide. By inhibiting these enzymes, Agmatine allows the “pump” from your other supplements (like Citrulline) to last significantly longer and feel much harder.

How Does Agmatine Increase Penis Size?

Agmatine supports size gains through three distinct pathways: extending the duration of erections, reducing penile nerve pain during stretching, and preventing tolerance to other supplements.

The Science: eNOS vs. iNOS

1. The “Pump” Multiplier:
Agmatine is unique because it selectively inhibits iNOS (inducible nitric oxide synthase), which breaks down NO, while stimulating eNOS (endothelial nitric oxide synthase), which creates vasodilation. This creates a “bottleneck” where Nitric Oxide builds up rapidly in the penile tissue.

2. Pain Modulation (NMDA Antagonist):
Agmatine interacts with NMDA receptors in the nervous system. This mildly dulls nerve pain. For men who use heavy mechanical tension (Hanging, Extending, or Clamping), Agmatine allows you to train at higher intensities with less discomfort.

3. Resetting Tolerance:
If you take pre-workouts or stimulants daily, you build a tolerance. Agmatine has been clinically shown to resensitize adrenergic receptors. Taking this ensures your body continues to respond to your other supplements month after month.

🚀 The “God Stack” for PE:

Agmatine is rarely taken alone. For the ultimate erection quality, combine 1,000mg Agmatine (The Multiplier) with 6,000mg Citrulline (The Fuel). The Agmatine prevents the Citrulline from breaking down, leading to an erection that feels “granite hard.”

✔ The Verdict: ADVANCED ESSENTIAL

5/5 Stars. This is the difference between a “good” routine and a “great” one. We highly recommend Agmatine for anyone currently using a pump or extender. It creates the optimal vascular environment for expansion and protects your nerves from overtraining.

Optimal Dosage
500mg – 1g
On Empty Stomach
30 min pre-workout

Safety Profile & Side Effects

Potential Side Effects:

Appetite Increase: Very common (Agmatine releases Ghrelin).
GI Upset: Only if taken with protein (Protein blocks absorption).

Interactions (Caution):

Alcohol: Do not mix. Increases ulcer risk.
L-Arginine: Do not take at exact same time (they compete for absorption).

Data source: Examine / PubMed

Perfect Synergy With:

⛽

L-Citrulline

Provides the raw fuel for the pump.
🧱

L-Glycine

Supports structural tissue repair.

Reality Check: Nutritional supplements create the biological environment for growth, but they do not cause size gains on their own.