Bioperine (The Absorption Multiplier)

Also Known As: Piperine, Black Pepper Extract, Piper Nigrum

Compound Type: Bioavailability Enhancer / Thermogenic

★★★★★ (5/5 Stars) MANDATORY ADD-ON

Bioperine is the “Secret Weapon” of advanced supplementation. It does not grow the penis directly, but without it, you are flushing 90% of your money down the toilet. Most supplements (especially herbal ones like Curcumin and Tribulus) have terrible “bioavailability,” meaning your liver destroys them before they reach your bloodstream.

Bioperine inhibits the enzymes that break down these nutrients. By adding just 10mg of Bioperine to your stack, you can increase the absorption of other compounds by up to 2,000%.

How Does It Help Size?

It makes your other supplements work. If you are taking Citrulline for pumps or Curcumin for inflammation, Bioperine ensures the active ingredients actually survive digestion to reach the penile tissue.

The Science: Glucuronidation Inhibition

1. The “2000%” Effect:
The most famous study on Piperine (published in Planta Medica) showed that when taken with Curcumin, serum levels of Curcumin increased by 2,000%. Without Piperine, the Curcumin was almost undetectable in the blood.

2. Slowing The Liver (Glucuronidation):
Your liver uses a process called glucuronidation to flag foreign substances for removal. Bioperine temporarily inhibits this process. This “opens the gates,” allowing supplements to circulate in your blood for hours longer than normal.

3. Thermogenesis:
Like Ginger, Bioperine increases metabolic heat energy. This improves intestinal transport, physically pushing nutrients through the gut wall more efficiently.

🧬 The “Co-Pilot” Rule:

Never take it alone.
Bioperine is useless on its own. Always take 5mg – 10mg alongside your most expensive supplements (like CoQ10, Curcumin, or your Pre-Workout). It acts as the delivery driver for the payload.

✔ The Verdict: STACK ESSENTIAL

5/5 Stars. This is the smartest 10 cents you can spend per day. If you are serious about PE and take multiple supplements, Bioperine acts as an insurance policy that your body is actually absorbing them.

Optimal Dosage
5mg – 10mg
With Supplements
Do not exceed 20mg

Safety Profile & Side Effects

Potential Side Effects:

  • GI Irritation: It is concentrated pepper; taking too much can burn the stomach lining.
  • Drug Potentiation: It makes EVERYTHING stronger, including prescription meds.
Interactions (DANGER):

  • Prescriptions: Do NOT take with blood thinners, antidepressants, or heart meds without a doctor. It can cause an accidental overdose by preventing the breakdown of the drug.

Data source: St. John’s Medical / PubMed

Perfect Synergy With:

  • 🟠
    Turmeric (Curcumin)

    The “Golden Standard” stack. Bioperine increases efficacy by 2000%.

  • ❤️
    CoQ10

    Another hard-to-absorb nutrient that requires Bioperine for uptake.

Reality Check: Bioperine is a catalyst. It does nothing on its own.

It helps you absorb the nutrients that fuel growth, but actual enlargement requires mechanical stress (Training). Visit PhalloPhysics.com.