Horny Goat Weed (Epimedium) is a flowering plant that is claimed to enhance libido and sex drive. The effects are said to have been discovered by a goat herder who noticed a significant increase in mating activities after the goats have consumed the herb. Since then, epimedium has been an active ingredient in many male enhancement supplements, and the subject of many clinical studies.
How Does Epimedium Enhance PE?
An ingredient known as icariin is said to enhance nitric oxide levels in the blood, therefore improving blood flow, and relaxes smooth muscle. The effectiveness of epimedium to enhance libido is well documented. There is little if any opposition to whether or not epimedium can truly increase the normal blood flow to the penis.
Do We Recommend Taking Epimedium?
We strongly suggest taking epimedium in one form or another to supplement your penis enlargement program, there is almost no question about its effectiveness.
How Do I Take Horny Goat Weed? There are many pill forms commercially available, there are liquid extracts, and herbal powder or leaves that can be used to make diffusions (tea) or mixed directly into a beverage (powder only). Like all penis enlargement supplements, we recommend taking epimedium in conjunction with various other supplements in different forms throughout the day.
Epimedium brevicornum Maxim extract relaxes rabbit corpus cavernosum through multitargets on nitric oxide/cyclic guanosine monophosphate signaling pathway. Chiu JH, Chen KK, Chien TM, Chiou WF, Chen CC, Wang JY, Lui WY, Wu CW. Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Peitou, Taipei, Taiwan, ROC.
Epimedium brevicornum Maxim (EbM) has been reputed to have sexual stimulation effects on males. The study is aimed to test the hypothesis that EbM extracts relaxed the corpus cavernosum (CC) smooth muscle through activation of multitargets on nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway.
Water extract of EbM and its subfraction (EP-20) were prepared and standardized by high-performance liquid chromatography. Isolated rabbit CC strips were mounted in organ baths and isometric tension was recorded in the presence or absence of specific inhibitors related to NO/cGMP signaling such as L-N(G)-nitro-arginine methyl ester (L-NAME), 1H-[1,2,4]oxadiazolo-[4,3-a] quinoxalin-1-one (ODQ, a guanylyl cyclase inhibitor) or phosphodiesterase 5 (PDE 5) inhibitors. cGMP level was determined in EP-20-treated CC strips. The results showed that EP-20 enriched the content of L-arginine in the process of purification and relaxed the CC smooth muscle precontracted with phenylephrine (PE, 1 microM) in a concentration-dependent manner. Besides, EP-20 increased the amount of cGMP production in rabbit CC tissues. Coincubation with EP-20 and L-NAME or ODQ significantly decreased EP-20-induced relaxation whereas EP-20 increased sodium nitroprusside-induced relaxation in PE-precontracted CC strips. Besides, EP-20 increased the potency and the duration of the relaxation effects caused by electrical field stimulation. Finally, EP-20 could potentiate PDE 5 inhibitors in relaxation of PE-precontracted CC strips. We concluded that extract of EbM relax the CC smooth muscle through multitargets in NO/cGMP/PDE 5 pathway and might bring into perspective the treatment strategy for those patients with erectile dysfunction.
Conclusion – Epimedium can be an effective male enhancement supplement