Vitamin B6 (The Prolactin Control)
Also Known As: Pyridoxine HCl, P-5-P (Pyridoxal-5-Phosphate)
Compound Type: Essential Vitamin / Prolactin Inhibitor / Neuro-Support
Vitamin B6 is often treated as a boring “multivitamin” ingredient, but in the context of male enhancement, it is a powerhouse. It is the primary cofactor required to synthesize Dopamine, Serotonin, and GABA.
Most importantly for PE, Vitamin B6 is a potent **Prolactin Inhibitor**. Prolactin is the “anti-erection” hormone released after orgasm. By keeping Prolactin low, B6 reduces your refractory period (the wait time between rounds) and prevents “sexual exhaustion” from frequent training.
How Does Vitamin B6 Help Size?
It manages the hormones that kill your erection (Prolactin) and aids in the absorption of Zinc and Magnesium.
The Science: P5P & Refractory Period
1. Crushing Prolactin:
A study in human subjects showed that high-dose Vitamin B6 caused a significant decrease in Prolactin levels and a rise in Growth Hormone. This makes it crucial for men who experience “Deca Dick” (drug-induced ED) or simply take too long to recover after sex.
2. The ZMA Synergy:
You rarely see Zinc and Magnesium sold without B6. Why? Because B6 aids the cellular uptake of Magnesium. Without enough B6, the expensive Magnesium you take for sleep and relaxation won’t be absorbed efficiently.
3. Dopamine Synthesis:
B6 is the rate-limiting cofactor in the conversion of L-Dopa to Dopamine. If you are taking Mucuna Pruriens, you must have adequate B6 levels, or the supplement simply won’t work.
Choose P-5-P over Pyridoxine.
Standard Vitamin B6 (Pyridoxine HCl) has to be converted by your liver to become active. P-5-P (Pyridoxal-5-Phosphate) is the “active” form. It works instantly and carries a much lower risk of nerve toxicity.
✔ The Verdict: STACK ESSENTIAL
5/5 Stars. Whether you use the ZMA stack for sleep or Mucuna for dopamine, B6 is the glue that holds it all together. It is cheap, effective, and keeps your refractory period short.
50mg – 100mg
P-5-P Form
Daily with food
Safety Profile & Side Effects
- Neuropathy (Warning): Taking massive doses (>200mg) of Pyridoxine HCl for years can cause temporary nerve damage (tingling fingers). P-5-P does not typically have this issue.
- Levodopa: B6 speeds up the breakdown of Levodopa medications.
Data source: Examine / PubMed



